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Hi Dr. Prasad, We had a similar patient who was diagnosed with KMT2A-R B ALL at 6 months of age, had a poor response to induction, progressed through consolidation, and experienced a lineage switch to a predominantly myeloid population following salvage ...

What a challenging case. Novel regimens which the patient has not seen include gemtuzumab with venetoclax and a demethylating agent which has been utilized by a few centers. Also clofarabine could be useful as well. Good luck. ------------------------------ ...

Hi everyone, hoping for guidance with a difficult situation of infantile ALL with lineage transformation.   We have the privilege of taking care of a kiddo with infantile ALL; she was diagnosed with pre-B (r-MLL) at 7 months of age.  We initially treated ...